PYC1 pyruvate carboxylase 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PYC1
Official Full Name: pyruvate carboxylase 1
Primary source: SGD:S000003030
Locus tag: YGL062W
See related: AllianceGenome:SGD:S000003030; FungiDB:YGL062W; VEuPathDB:YGL062W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables pyruvate carboxylase activity. Involved in gluconeogenesis. Located in cytosol. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PYC1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (385196..388732)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glu40 and Glu433 play essential roles in subunit interactions.
Title: Conserved Glu40 and Glu433 of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pyruvate carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate carboxylase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate carboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in small molecule biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pyruvate carboxylase 1

NP_011453.1

EC 6.4.1.1

Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

385196..388732

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180927.1 → NP_011453.1 TPA: pyruvate carboxylase 1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011453.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VU79, P11154

UniProtKB/TrEMBL

N1P377

Conserved Domains (7) summary

cd06850
Location:1102 → 1168

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:559 → 840

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:359 → 466

Biotin_carb_C; Biotin carboxylase C-terminal domain

COG1038
Location:14 → 1170

PycA; Pyruvate carboxylase [Energy production and conversion]

pfam00289
Location:20 → 130

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:851 → 1050

PYC_OADA; Conserved carboxylase domain

pfam02786
Location:135 → 329

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain