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HEM2 porphobilinogen synthase HEM2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852842, updated on 17-May-2024

Summary

Gene symbol
HEM2
Gene description
porphobilinogen synthase HEM2
Primary source
FungiDB:YGL040C
Locus tag
YGL040C
See related
SGD:S000003008; AllianceGenome:SGD:S000003008; VEuPathDB:YGL040C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
OLE4; SLU1
Summary
Enables porphobilinogen synthase activity and zinc ion binding activity. Involved in heme biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HEM2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (419527..420555, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription elongation factor DST1 Neighboring gene uncharacterized protein Neighboring gene Dpc13p Neighboring gene tRNA-Leu Neighboring gene carbonyl reductase (NADPH-dependent)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables porphobilinogen synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables porphobilinogen synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables porphobilinogen synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables porphobilinogen synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
porphobilinogen synthase HEM2
NP_011475.1
  • Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; human homolog ALAD can complement yeast hem2 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    419527..420555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180905.1NP_011475.1  TPA: porphobilinogen synthase HEM2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011475.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU99, P05373
    UniProtKB/TrEMBL
    A0A6A5PVL1, A6ZUV5, B3LIQ1, C7GS20, C8Z8K3, G2WE55, N1P5J0
    Conserved Domains (1) summary
    cd04824
    Location:20338
    eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...