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OCH1 initiation-specific alpha-1,6-mannosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852845, updated on 28-Oct-2024

Summary

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Official Symbol
OCH1
Official Full Name
initiation-specific alpha-1,6-mannosyltransferase
Primary source
SGD:S000003006
Locus tag
YGL038C
See related
AllianceGenome:SGD:S000003006; FungiDB:YGL038C; VEuPathDB:YGL038C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LDB12; NGD29
Summary
Enables alpha-1,6-mannosyltransferase activity. Involved in protein N-linked glycosylation. Located in Golgi cis cisterna. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See OCH1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (425362..426804, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene carbonyl reductase (NADPH-dependent) Neighboring gene nicotinamidase Neighboring gene Vir1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative functional analysis of the OCH1 mannosyltransferase families in Aspergillus fumigatus and Saccharomyces cerevisiae. Lambou K, et al. Yeast, 2010 Aug. PMID 20586114
  2. OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides. Nakayama K, et al. EMBO J, 1992 Jul. PMID 1628616, Free PMC Article
  3. Glycoprotein biosynthesis in Saccharomyces cerevisiae: ngd29, an N-glycosylation mutant allelic to och1 having a defect in the initiation of outer chain formation. Lehle L, et al. FEBS Lett, 1995 Aug 14. PMID 7649302
  4. Glycoprotein biosynthesis in Saccharomyces cerevisiae. Partial purification of the alpha-1,6-mannosyltransferase that initiates outer chain synthesis. Romero PA, et al. Glycobiology, 1994 Apr. PMID 8054713
  5. Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae. Nakanishi-Shindo Y, et al. J Biol Chem, 1993 Dec 15. PMID 8253757

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metabolism of free oligosaccharides is facilitated in the och1Delta mutant of Saccharomyces cerevisiae.
    Title: Metabolism of free oligosaccharides is facilitated in the och1Δ mutant of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,6-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,6-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,6-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-1,6-mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycolipid 1,6-alpha-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate derivative metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cis cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mannan polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
initiation-specific alpha-1,6-mannosyltransferase
NP_011477.1
  • Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    425362..426804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180903.1 → NP_011477.1  TPA: initiation-specific alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011477.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUA1, P31755
    UniProtKB/TrEMBL
    A6ZUV7, B3LIP9, B5VIS8, C7GT53, C8Z8K5, G2WE57, N1P1Y4
    Conserved Domains (1) summary
    COG3774
    Location:5 → 410
    OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31755.1

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