RPL30 ribosomal 60S subunit protein L30 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: RPL30
Gene description: ribosomal 60S subunit protein L30
Primary source: FungiDB:YGL030W
Locus tag: YGL030W
See related: SGD:S000002998; AllianceGenome:SGD:S000002998; VEuPathDB:YGL030W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables pre-mRNA 5'-splice site binding activity. A structural constituent of ribosome. Involved in negative regulation of mRNA splicing, via spliceosome and rRNA processing. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Used to study cancer. Human ortholog(s) of this gene implicated in herpes simplex. Orthologous to human RPL30 (ribosomal protein L30). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RPL30 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 2

Sequence:: Chromosome: VII; NC_001139.9 (439091..439638)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

protein L30 blocks spliceosomal rearrangements required for the engagement of U2 snRNP (small ribonucleoprotein particle) to its own transcript RPL30
Title: RPL30 regulation of splicing reveals distinct roles for Cbp80 in U1 and U2 snRNP cotranscriptional recruitment.
screens identified a glycine to serine mutation of L30e, which specifically restores activity to an RNA variant containing a U that replaces a helix-capping G
Title: Compensatory mutations in the L30e kink-turn RNA-protein complex.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA 5'-splice site binding	IGI Inferred from Genetic Interaction more info	PubMed
enables pre-mRNA 5'-splice site binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal 60S subunit protein L30

NP_011485.1

Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

439091..439638

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180895.1 → NP_011485.1 TPA: ribosomal 60S subunit protein L30 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011485.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUA8, P14120

UniProtKB/TrEMBL

A6ZUW4, C8Z8L2, G2WE64

Conserved Domains (1) summary

PTZ00106
Location:5 → 104

PTZ00106; 60S ribosomal protein L30; Provisional