CWH41 mannosyl-oligosaccharide glucosidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CWH41
Gene description: mannosyl-oligosaccharide glucosidase
Primary source: FungiDB:YGL027C
Locus tag: YGL027C
See related: SGD:S000002995; AllianceGenome:SGD:S000002995; VEuPathDB:YGL027C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DER7; GLS1
Summary: Enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Involved in fungal-type cell wall beta-glucan biosynthetic process and protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CWH41 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (443642..446143, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The first structural model of eukaryotic GluI from Saccharomyces cereveisiae determined by X-ray crystallography.
Title: Specificity of Processing α-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies.
These findings indicate that the active conformation of the enzyme is not dependent on protein glycosylation and suggest that the M1-I28 region of Cwh41p carries an ER-targeting signal sequence.
Title: Truncations and functional carboxylic acid residues of yeast processing alpha-glucosidase I.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IEA Inferred from Electronic Annotation more info
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fungal-type cell wall beta-glucan biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fungal-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mannosyl-oligosaccharide glucosidase

NP_011488.1

EC 3.2.1.106

Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

443642..446143 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180892.1 → NP_011488.1 TPA: mannosyl-oligosaccharide glucosidase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011488.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUB1, P53008

UniProtKB/TrEMBL

A0A8H4FBG8, B3LIP0, B5VIT4, N1P3P4

Conserved Domains (2) summary

pfam03200
Location:319 → 832

Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain

pfam16923
Location:45 → 266

Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain