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PIB2 Pib2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852861, updated on 28-Oct-2024

Summary

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Official Symbol
PIB2
Official Full Name
Pib2p
Primary source
SGD:S000002991
Locus tag
YGL023C
See related
AllianceGenome:SGD:S000002991; FungiDB:YGL023C; VEuPathDB:YGL023C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-cysteine binding activity; amino acid sensor activity; and phosphatidylinositol-3-phosphate binding activity. Involved in positive regulation of TORC1 signaling. Located in mitochondrion. Is active in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PIB2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (450197..452104, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tryptophan synthase TRP5 Neighboring gene Pgd1p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 Neighboring gene protein kinase ALK1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional mapping of yeast genomes by saturated transposition. Michel AH, et al. Elife, 2017 May 8. PMID 28481201, Free PMC Article
  2. A glutamine sensor that directly activates TORC1. Tanigawa M, et al. Commun Biol, 2021 Sep 17. PMID 34535752, Free PMC Article
  3. Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation. Caligaris M, et al. Elife, 2023 Feb 7. PMID 36749016, Free PMC Article
  4. KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae. Kessi-Pérez EI, et al. Front Microbiol, 2019. PMID 31417508, Free PMC Article
  5. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Burd CG, et al. Mol Cell, 1998 Jul. PMID 9702203

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A glutamine sensor that directly activates TORC1.
    Title: A glutamine sensor that directly activates TORC1.
  2. Data suggest that Pib2 functioning as a putative glutamine sensor in the regulation of TORC1.
    Title: Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane.
  3. Pib2 and the EGO complex cooperate to activate TORC1 and connect phosphoinositide 3-kinase (PI3K) signaling and TORC1 activity.
    Title: Pib2 and the EGO complex are both required for activation of TORC1.
  4. These findings show novel roles of PI(3)P and Pib2 in the regulation of TORC1, which in turn promoted Lysosomal membrane permeabilization and nonapoptotic death of stressed cells
    Title: A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-cysteine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-cysteine binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables amino acid sensor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in bounding membrane of organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pib2p
NP_011492.3
  • Phosphatidylinositol 3-phosphate binding protein; forms a distinct complex with TORC1, induced by glutamine in a dose-dependent manner, resulting in TORC1 activation, suggesting dual roles as both a glutamine sensor and a direct TORC1 activator; functions as a cysteine sensor involved in TORC1 activation; involved in leucine- and glutamine-responsive TORC1 activation, independent of the Gtr/Ego pathway; related to human PLEKHF1; contains a PI3P binding FYVE domain; similar to Fab1p and Vps27p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    450197..452104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180888.3 → NP_011492.3  TPA: Pib2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011492.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUB4, E9P8Z2, P53191
    UniProtKB/TrEMBL
    A6ZUX0, N1P9S7
    Conserved Domains (1) summary
    smart00064
    Location:446 → 530
    FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53191.1

Gene LinkOut

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