U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PMA1 H(+)-exporting P2-type ATPase PMA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852876, updated on 28-Oct-2024

Summary

Official Symbol
PMA1
Official Full Name
H(+)-exporting P2-type ATPase PMA1
Primary source
SGD:S000002976
Locus tag
YGL008C
See related
AllianceGenome:SGD:S000002976; FungiDB:YGL008C; VEuPathDB:YGL008C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KTI10
Summary
Enables P-type proton-exporting transporter activity. Involved in positive regulation of TORC1 signaling; proteasome storage granule assembly; and proton transmembrane transport. Located in eisosome; membrane raft; and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PMA1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (479910..482666, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mpo1p Neighboring gene 3-isopropylmalate dehydratase LEU1 Neighboring gene uncharacterized protein Neighboring gene Brp1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type ion transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type proton-exporting transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables P-type proton-exporting transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables P-type proton-exporting transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables inorganic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in inorganic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome storage granule assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proton export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proton transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in eisosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
H(+)-exporting P2-type ATPase PMA1
NP_011507.1
  • Plasma membrane P2-type H+-ATPase; pumps protons out of cell; major regulator of cytoplasmic pH and plasma membrane potential; long-lived hexameric protein asymmetrically distributed at plasma membrane between mother cells and buds; accumulates at high levels in mother cells during aging, buds emerge with very low levels of Pma1p, newborn cells have low levels of Pma1p; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    479910..482666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180873.1NP_011507.1  TPA: H(+)-exporting P2-type ATPase PMA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011507.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUC9, P05030
    UniProtKB/TrEMBL
    A6ZUY5, B3LIM3, C7GK65, N1P3Q6
    Conserved Domains (1) summary
    cd02076
    Location:87874
    P-type_ATPase_H; plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases