CAX4 dolichyldiphosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CAX4
Official Full Name: dolichyldiphosphatase
Primary source: SGD:S000003268
Locus tag: YGR036C
See related: AllianceGenome:SGD:S000003268; FungiDB:YGR036C; VEuPathDB:YGR036C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CWH8
Summary: Enables dolichyldiphosphatase activity. Involved in lipid biosynthetic process and protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Orthologous to human DOLPP1 (dolichyldiphosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CAX4 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (558149..558868, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dolichyldiphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables dolichyldiphosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in carbohydrate derivative biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dolichyldiphosphatase

NP_011550.3

EC 3.6.1.43

Dolichyl pyrophosphate (Dol-P-P) phosphatase; cleaves the anhydride linkage in Dol-P-P; involved in synthesis of Dol-P-P-linked oligosaccharide intermediate required for protein N-glycosylation; has a luminally oriented active site in the ER; mutation affects vesicular transport, membrane and cell wall biogenesis and lipid homeostasis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

558149..558868 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181165.3 → NP_011550.3 TPA: dolichyldiphosphatase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011550.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUH3, P53223, Q45U47

UniProtKB/TrEMBL

A6ZV25, B3LII4, B5VIZ3, C7GKA3, C8Z8T2, G2WEC7, N1P5Q1

Conserved Domains (1) summary

cd03382
Location:17 → 179

PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...