ACB1 long-chain fatty acid transporter ACB1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ACB1
Official Full Name: long-chain fatty acid transporter ACB1
Primary source: SGD:S000003269
Locus tag: YGR037C
See related: AllianceGenome:SGD:S000003269; FungiDB:YGR037C; VEuPathDB:YGR037C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables long-chain fatty acyl-CoA binding activity. Involved in very long-chain fatty acid biosynthetic process. Located in extracellular region. Used to study cardiovascular system disease. Orthologous to several human genes including DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ACB1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (559731..559994, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1.
Title: Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1.
The major ESCRT-III subunit Snf7 localizes transiently to vesicles and tubules surrounded by a cup-shaped membrane and this was accelerated in vps4Delta cells, correlating with increased Acb1 secretion.
Title: ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.
These experiments reveal a unique secretory pathway where autophagosomes containing Acb1 evade fusion with the vacuole to prevent cargo degradation.
Title: Unconventional secretion of Acb1 is mediated by autophagosomes.
study of the cardiolipin species profile in Saccharomyces cerevisiae by using depletion of the acyl-CoA-binding protein Acb1p
Title: Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: new insights into acyl chain remodeling of cardiolipin.
phospholipid biosynthesis gene expression is modulated either by the Acb1p-acyl-CoA ester complex directly or by its ability to donate acyl-CoA esters to utilizing systems.
Title: Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acyl-CoA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: long-chain fatty acid transporter ACB1

NP_011551.3

Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

559731..559994 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181166.3 → NP_011551.3 TPA: long-chain fatty acid transporter ACB1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011551.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUH4, P31787, Q45U46

UniProtKB/TrEMBL

A6ZV26, B3LII3, C7GKA4, C8Z8T3, G2WEC8, N1P3G4

Conserved Domains (1) summary

COG4281
Location:1 → 87

ACB; Acyl-CoA-binding protein [Lipid transport and metabolism]