TAM41 putative phosphatidate cytidylyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TAM41
Official Full Name: putative phosphatidate cytidylyltransferase
Primary source: SGD:S000003278
Locus tag: YGR046W
See related: AllianceGenome:SGD:S000003278; FungiDB:YGR046W; VEuPathDB:YGR046W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MMP37
Summary: Enables phosphatidate cytidylyltransferase activity. Involved in cardiolipin biosynthetic process. Located in mitochondrial matrix. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 56. Orthologous to human TAMM41 (TAM41 mitochondrial translocator assembly and maintenance homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TAM41 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (584895..586052)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inositol depletion by overexpressing an arrestin-related protein Art5 partially restores the defects of cell growth and CL synthesis in the absence of Tam41.
Title: Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria.
Art5 indentified as a functional partner for Tam41 in the present study will provide a starting point to reveal the precise mechanism of apparently promiscuous functions of Tam41 in the maintenance of the TIM23 complex.
Title: Identification of yeast Art5 as a multicopy suppressor for the mitochondrial translocator maintenance protein Tam41.
Tam41 is required for the biosynthesis of the dimeric phospholipid cardiolipin.
Title: The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis.
Mmp37p enhances the early stages of the TIM23 matrix import pathway to ensure engagement of incoming preproteins with the mtHsp70p/PAM complex, a step that is necessary to drive the unfolding and complete translocation of the preprotein into the matrix.
Title: Characterization of Mmp37p, a Saccharomyces cerevisiae mitochondrial matrix protein with a role in mitochondrial protein import.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate cytidylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate cytidylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate cytidylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate cytidylyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardiolipin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative phosphatidate cytidylyltransferase

NP_011560.3

EC 2.7.7.41

Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

584895..586052

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181175.3 → NP_011560.3 TPA: putative phosphatidate cytidylyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011560.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUI3, P53230, Q45U38

UniProtKB/TrEMBL

A6ZV33, B3LIH5, B5VIZ8, C7GXN1, N1P9V1

Conserved Domains (1) summary

pfam09139
Location:113 → 380

Mmp37; Mitochondrial matrix Mmp37