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ERG25 methylsterol monooxygenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852951, updated on 2-Nov-2024

Summary

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Official Symbol
ERG25
Official Full Name
methylsterol monooxygenase
Primary source
SGD:S000003292
Locus tag
YGR060W
See related
AllianceGenome:SGD:S000003292; FungiDB:YGR060W; VEuPathDB:YGR060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables C-4 methylsterol oxidase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane and plasma membrane. Is active in endoplasmic reticulum. Orthologous to human MSMO1 (methylsterol monooxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERG25 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (610564..611493)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene septin SPR3 Neighboring gene ncRNA Neighboring gene phosphoribosylformylglycinamidine synthase Neighboring gene membrane insertase COX18

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and functional identification of C-4 methyl sterol oxidase genes from the penicillin-producing fungus Penicillium chrysogenum. Wang FQ, et al. FEMS Microbiol Lett, 2008 Oct. PMID 18707625
  2. Inhibition of sterol biosynthesis reduces tombusvirus replication in yeast and plants. Sharma M, et al. J Virol, 2010 Mar. PMID 20015981, Free PMC Article
  3. Enzymological properties of sterol-C4-methyl-oxidase of yeast sterol biosynthesis. Darnet S, et al. Biochim Biophys Acta, 2003 Jul 21. PMID 12880870
  4. Isolation of temperature-sensitive Saccharomyces cerevisiae with a mutation in erg25 for C-4 sterol methyl oxidase. Nose H, et al. J Antibiot (Tokyo), 2002 Nov. PMID 12546417
  5. Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. Li L, et al. J Biol Chem, 1996 Jul 12. PMID 8663358

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.
    Title: The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables C-4 methylsterol oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-4 methylsterol oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables C-4 methylsterol oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables C-4 methylsterol oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
methylsterol monooxygenase
NP_011574.3
  • C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    610564..611493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181189.3 → NP_011574.3  TPA: methylsterol monooxygenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011574.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUJ5, E9P8T3, P53045, Q45U26
    UniProtKB/TrEMBL
    A6ZV45, B3LIG3, B5VJ10, C7GXP3, C8Z8V4, G2WEE7, N1P254
    Conserved Domains (1) summary
    COG3000
    Location:35 → 307
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53045.1

Gene LinkOut

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