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PRP38 U4/U6-U5 snRNP complex subunit PRP38 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852966, updated on 2-Nov-2024

Summary

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Official Symbol
PRP38
Official Full Name
U4/U6-U5 snRNP complex subunit PRP38
Primary source
SGD:S000003307
Locus tag
YGR075C
See related
AllianceGenome:SGD:S000003307; FungiDB:YGR075C; VEuPathDB:YGR075C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11). Part of U4/U6 x U5 tri-snRNP complex. Used to study cancer. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PRP38 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (636147..636875, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Env11p Neighboring gene Upf3p Neighboring gene mRNA splicing protein SMD1 Neighboring gene mitochondrial 54S ribosomal protein YmL25 Neighboring gene Pex8p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. Blanton S, et al. Mol Cell Biol, 1992 Sep. PMID 1508195, Free PMC Article
  2. Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation. Xie J, et al. EMBO J, 1998 May 15. PMID 9582287, Free PMC Article
  3. Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation. Lybarger S, et al. Mol Cell Biol, 1999 Jan. PMID 9858581, Free PMC Article
  4. Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor. Ulrich AK, et al. BMC Evol Biol, 2017 Mar 24. PMID 28335716, Free PMC Article
  5. Inhibition of a spliceosome turnover pathway suppresses splicing defects. Pandit S, et al. Proc Natl Acad Sci U S A, 2006 Sep 12. PMID 16945917, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U4/U6-U5 snRNP complex subunit PRP38
NP_011589.3
  • Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    636147..636875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181204.3 → NP_011589.3  TPA: U4/U6-U5 snRNP complex subunit PRP38 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011589.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUK7, Q00723
    UniProtKB/TrEMBL
    A6ZV57, B3LIF1, B5VJ21, C7GXQ4, C8Z8W9, G2WEF9, N1P3X3
    Conserved Domains (1) summary
    pfam03371
    Location:15 → 211
    PRP38; PRP38 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00723.1

Gene LinkOut

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