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TWF1 Twf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852971, updated on 2-Nov-2024

Summary

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Official Symbol
TWF1
Official Full Name
Twf1p
Primary source
SGD:S000003312
Locus tag
YGR080W
See related
AllianceGenome:SGD:S000003312; FungiDB:YGR080W; VEuPathDB:YGR080W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables actin filament binding activity and actin monomer binding activity. Involved in actin cytoskeleton organization; actin filament severing; and regulation of actin polymerization or depolymerization. Located in actin filament. Orthologous to several human genes including TWF2 (twinfilin actin binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TWF1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (642010..643008)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tubulin-binding prefolding complex subunit PAC10 Neighboring gene uncharacterized protein Neighboring gene Slx9p Neighboring gene Tom20p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ADF homology (ADF-H) domain: a highly exploited actin-binding module. Lappalainen P, et al. Mol Biol Cell, 1998 Aug. PMID 9693358, Free PMC Article
  2. Species-Specific Functions of Twinfilin in Actin Filament Depolymerization. Hilton DM, et al. J Mol Biol, 2018 Sep 14. PMID 29928893, Free PMC Article
  3. Regulation of the cortical actin cytoskeleton in budding yeast by twinfilin, a ubiquitous actin monomer-sequestering protein. Goode BL, et al. J Cell Biol, 1998 Aug 10. PMID 9700161, Free PMC Article
  4. High-speed depolymerization at actin filament ends jointly catalysed by Twinfilin and Srv2/CAP. Johnston AB, et al. Nat Cell Biol, 2015 Nov. PMID 26458246, Free PMC Article
  5. Biological role and structural mechanism of twinfilin-capping protein interaction. Falck S, et al. EMBO J, 2004 Aug 4. PMID 15282541, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Twinfilin and Srv2 proteins accelerate depolymerization from actin filament ends.
    Title: High-speed depolymerization at actin filament ends jointly catalysed by Twinfilin and Srv2/CAP.
  2. Together, our data suggest that twinfilin coordinates filament severing and monomer sequestering at sites of rapid actin turnover and is controlled by multiple regulatory inputs.
    Title: Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo.
  3. binding of twinfilin to capping protein does not affect the binding of either protein to actin
    Title: Biological role and structural mechanism of twinfilin-capping protein interaction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cortical patch organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament severing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament severing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of actin monomers IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip HDA PubMed 

General protein information

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Preferred Names
Twf1p
NP_011594.3
  • Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, stimulates actin depolymerization as does the mouse homolog, mTwf1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    642010..643008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181209.3 → NP_011594.3  TPA: Twf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011594.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUL2, P53250
    UniProtKB/TrEMBL
    A6ZV62, B3LIE6, B5VJ24, C7GXQ9, C8Z8X4, G2WEG4, N1P3X8
    Conserved Domains (2) summary
    cd11284
    Location:175 → 297
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4 → 124
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53250.1

Gene LinkOut

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