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MDR1 GTPase-activating protein MDR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852992, updated on 18-Sep-2024

Summary

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Official Symbol
MDR1
Official Full Name
GTPase-activating protein MDR1
Primary source
SGD:S000003332
Locus tag
YGR100W
See related
AllianceGenome:SGD:S000003332; FungiDB:YGR100W; VEuPathDB:YGR100W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GYP2; MIC1
Summary
Enables GTPase activator activity. Involved in activation of GTPase activity. Located in cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome type 20. Orthologous to several human genes including TBC1D8 (TBC1 domain family member 8); TBC1D8B (TBC1 domain family member 8B); and TBC1D9 (TBC1 domain family member 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MDR1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (690245..693097)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene separase Neighboring gene Tel2p Neighboring gene rhomboid protease PCP1 Neighboring gene glutamyl-tRNA(Gln) amidotransferase subunit F

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Opposite roles of the F-box protein Rcy1p and the GTPase-activating protein Gyp2p during recycling of internalized proteins in yeast. Lafourcade C, et al. Genetics, 2003 Jun. PMID 12807768, Free PMC Article
  2. The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Lachmann J, et al. Mol Biol Cell, 2012 Jul. PMID 22593206, Free PMC Article
  3. A positive feedback loop involving the Spa2 SHD domain contributes to focal polarization. Lawson MJ, et al. PLoS One, 2022. PMID 35134079, Free PMC Article
  4. Involvement of Golgi-associated retrograde protein complex in the recycling of the putative Dnf aminophospholipid flippases in yeast. Takagi K, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22177957
  5. Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast. Bi E, et al. Mol Biol Cell, 2000 Feb. PMID 10679030, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of polarized growth IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTPase-activating protein MDR1
NP_011614.1
  • Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    690245..693097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181229.1 → NP_011614.1  TPA: GTPase-activating protein MDR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011614.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUN2, P53258
    UniProtKB/TrEMBL
    A6ZV82, B3LIC6, C7GWW3, C8Z8Z3
    Conserved Domains (1) summary
    COG5210
    Location:23 → 531
    COG5210; GTPase-activating protein [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53258.1

Gene LinkOut

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