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SYF2 Syf2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853030, updated on 18-Sep-2024

Summary

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Official Symbol
SYF2
Official Full Name
Syf2p
Primary source
SGD:S000003361
Locus tag
YGR129W
See related
AllianceGenome:SGD:S000003361; FungiDB:YGR129W; VEuPathDB:YGR129W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NTC31
Summary
Predicted to contribute to first spliceosomal transesterification activity and second spliceosomal transesterification activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nucleus. Part of Prp19 complex and U2-type spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SYF2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (750400..751047)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Utp8p Neighboring gene uncharacterized protein Neighboring gene Fhn1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. Dahan O, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384582, Free PMC Article
  2. Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae. Russell CS, et al. RNA, 2000 Nov. PMID 11105756, Free PMC Article
  3. Functional and physical interactions between components of the Prp19p-associated complex. Chen CH, et al. Nucleic Acids Res, 2002 Feb 15. PMID 11842115, Free PMC Article
  4. The Spliceosome: A Protein-Directed Metalloribozyme. Shi Y. J Mol Biol, 2017 Aug 18. PMID 28733144
  5. Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway. Yeh TC, et al. Mol Cell Biol, 2011 Jan. PMID 20956557, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to first spliceosomal transesterification activity IC
Inferred by Curator
more info
 PubMed 
contributes_to second spliceosomal transesterification activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type catalytic step 1 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type post-mRNA release spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type prespliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Syf2p
NP_011645.3
  • Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    750400..751047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181258.3 → NP_011645.3  TPA: Syf2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011645.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUR1, P53277
    UniProtKB/TrEMBL
    A6ZUE3, B3LI99, B5VJ75, C7GUG6, C8Z922, G2WEL1, N1P3R2
    Conserved Domains (1) summary
    pfam08231
    Location:60 → 209
    SYF2; SYF2 splicing factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53277.1

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