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FHN1 Fhn1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853032, updated on 18-Sep-2024

Summary

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Official Symbol
FHN1
Official Full Name
Fhn1p
Primary source
SGD:S000003363
Locus tag
YGR131W
See related
AllianceGenome:SGD:S000003363; FungiDB:YGR131W; VEuPathDB:YGR131W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein localization to plasma membrane. Located in cell periphery. Colocalizes with eisosome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FHN1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (754726..755250)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Syf2p Neighboring gene uncharacterized protein Neighboring gene prohibitin subunit PHB1 Neighboring gene E2 ubiquitin-protein ligase peroxin 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plasma Membrane Protein Nce102 Modulates Morphology and Function of the Yeast Vacuole. Vaskovicova K, et al. Biomolecules, 2020 Oct 23. PMID 33114062, Free PMC Article
  2. Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae. Agarwal AK, et al. J Biol Chem, 2003 Sep 12. PMID 12824174
  3. C terminus of Nce102 determines the structure and function of microdomains in the Saccharomyces cerevisiae plasma membrane. Loibl M, et al. Eukaryot Cell, 2010 Aug. PMID 20581291, Free PMC Article
  4. Plasma membrane microdomains regulate turnover of transport proteins in yeast. Grossmann G, et al. J Cell Biol, 2008 Dec 15. PMID 19064668, Free PMC Article
  5. The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways. Woods K, et al. Mol Microbiol, 2016 Feb. PMID 26448198

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in eisosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in eisosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fhn1p
NP_011647.1
  • hypothetical protein; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; FHN1 has a paralog, NCE102, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    754726..755250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181260.1 → NP_011647.1  TPA: Fhn1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011647.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUR3, P53279
    UniProtKB/TrEMBL
    A6ZUE5, B3LI97, C7GUG4, C8Z924, G2WEL3, N1P9W8
    Conserved Domains (1) summary
    pfam01284
    Location:6 → 138
    MARVEL; Membrane-associating domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53279.1

Gene LinkOut

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