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LSB1 Lsb1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853037, updated on 2-Nov-2024

Summary

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Official Symbol
LSB1
Official Full Name
Lsb1p
Primary source
SGD:S000003368
Locus tag
YGR136W
See related
AllianceGenome:SGD:S000003368; FungiDB:YGR136W; VEuPathDB:YGR136W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in negative regulation of Arp2/3 complex-mediated actin nucleation. Located in actin cortical patch. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LSB1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (762428..763153)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene CCR4-NOT core subunit CAF130 Neighboring gene proteasome core particle subunit alpha 3 Neighboring gene spermine transporter Neighboring gene Cbf2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis. Spiess M, et al. PLoS One, 2013. PMID 23577202, Free PMC Article
  2. Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro. Kaminska J, et al. Eur J Cell Biol, 2011 Dec. PMID 22000681
  3. The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins. Körner C, et al. Cell Rep, 2024 Aug 27. PMID 39167489
  4. Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton. Chernova TA, et al. Mol Cell, 2011 Jul 22. PMID 21777813, Free PMC Article
  5. Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion. Ali M, et al. J Biol Chem, 2014 Oct 3. PMID 25143386, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lsb1 is crucial for prion maintenance during stress.
    Title: Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.
  2. Lsb1 and/or Lsb2 full-length proteins inhibit Las17-mediated actin polymerization
    Title: Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lsb1p
NP_011652.1
  • Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    762428..763153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181265.1 → NP_011652.1  TPA: Lsb1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011652.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUR8, P53281
    UniProtKB/TrEMBL
    A6ZUF0, B3LI92, C7GUF9, C8Z929, G2WEL8, N1P433
    Conserved Domains (2) summary
    smart00326
    Location:55 → 108
    SH3; Src homology 3 domains
    PRK14971
    Location:100 → 156
    PRK14971; DNA polymerase III subunit gamma/tau
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53281.1

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