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RBG2 Rbg2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853083, updated on 2-Nov-2024

Summary

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Official Symbol
RBG2
Official Full Name
Rbg2p
Primary source
SGD:S000003405
Locus tag
YGR173W
See related
AllianceGenome:SGD:S000003405; FungiDB:YGR173W; VEuPathDB:YGR173W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GIR1
Summary
Predicted to enable GTP binding activity. Involved in cytoplasmic translation and positive regulation of cellular response to amino acid starvation. Located in cytoplasm. Orthologous to human DRG2 (developmentally regulated GTP binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RBG2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (843854..844960)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene methionine--tRNA ligase MSM1 Neighboring gene transporter YIP1 Neighboring gene tRNA-Gly Neighboring gene Cbp4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation. Ishikawa K, et al. Genes Cells, 2013 Oct. PMID 23899355
  2. Structure of Gcn1 bound to stalled and colliding 80S ribosomes. Pochopien AA, et al. Proc Natl Acad Sci U S A, 2021 Apr 6. PMID 33790014, Free PMC Article
  3. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells. Zeng F, et al. Cell Rep, 2021 Oct 26. PMID 34706231, Free PMC Article
  4. DRG represents a family of two closely related GTP-binding proteins. Li B, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760581
  5. Loss of vacuolar proton-translocating ATPase activity in yeast results in chronic oxidative stress. Milgrom E, et al. J Biol Chem, 2007 Mar 9. PMID 17215245

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cellular response to amino acid starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rbg2p
NP_011689.1
  • Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    843854..844960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181302.1 → NP_011689.1  TPA: Rbg2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011689.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUV7, P53295
    UniProtKB/TrEMBL
    A6ZUI5, B3LI57, C7GQ80, C8Z969, G2WEQ4, N1P469
    Conserved Domains (1) summary
    COG1163
    Location:1 → 368
    Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53295.1

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