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SKI6 exosome non-catalytic core subunit SKI6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853109, updated on 2-Nov-2024

Summary

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Official Symbol
SKI6
Official Full Name
exosome non-catalytic core subunit SKI6
Primary source
SGD:S000003427
Locus tag
YGR195W
See related
AllianceGenome:SGD:S000003427; FungiDB:YGR195W; VEuPathDB:YGR195W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ECM20; RRP41
Summary
Predicted to enable RNA binding activity. Involved in RNA metabolic process. Located in nucleolus. Part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Used to study developmental disorder of mental health. Orthologous to human EXOSC4 (exosome component 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SKI6 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (888882..889622)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Pdx1p Neighboring gene xylulokinase Neighboring gene Fyv8p Neighboring gene Sng1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The complete sequence of a 9000 bp fragment of the right arm of Saccharomyces cerevisiae chromosome VII contains four previously unknown open reading frames. Guerreiro P, et al. Yeast, 1995 Sep 15. PMID 7502584
  2. Poly(A) tail-dependent exonuclease AtRrp41p from Arabidopsis thaliana rescues 5.8 S rRNA processing and mRNA decay defects of the yeast ski6 mutant and is found in an exosome-sized complex in plant and yeast cells. Chekanova JA, et al. J Biol Chem, 2000 Oct 20. PMID 10930416
  3. Processing of 3'-extended read-through transcripts by the exosome can generate functional mRNAs. Torchet C, et al. Mol Cell, 2002 Jun. PMID 12086625
  4. 3' poly(A) is dispensable for translation. Searfoss AM, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922069, Free PMC Article
  5. Ski6p is a homolog of RNA-processing enzymes that affects translation of non-poly(A) mRNAs and 60S ribosomal subunit biogenesis. Benard L, et al. Mol Cell Biol, 1998 May. PMID 9566888, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TRAMP-dependent tRNA surveillance pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in TRAMP-dependent tRNA surveillance pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in U1 snRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in U1 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U4 snRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in U4 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in U5 snRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in U5 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear mRNA surveillance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear mRNA surveillance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear polyadenylation-dependent CUT catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in poly(A)-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)-dependent snoRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
  
part_of exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exosome non-catalytic core subunit SKI6
NP_011711.3
  • Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    888882..889622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181324.3 → NP_011711.3  TPA: exosome non-catalytic core subunit SKI6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011711.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUX7, P46948
    UniProtKB/TrEMBL
    A6ZUK5, B3LI42, B5VJD7, C7GRM7, C8Z988, G2WES3, N1P625
    Conserved Domains (1) summary
    cd11370
    Location:11 → 237
    RNase_PH_RRP41; RRP41 subunit of eukaryotic exosome
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46948.1

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