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MVB12 ubiquitin-binding ESCRT-I subunit protein MVB12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853120, updated on 18-Sep-2024

Summary

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Official Symbol
MVB12
Official Full Name
ubiquitin-binding ESCRT-I subunit protein MVB12
Primary source
SGD:S000003438
Locus tag
YGR206W
See related
AllianceGenome:SGD:S000003438; FungiDB:YGR206W; VEuPathDB:YGR206W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin binding activity. Involved in ATP export; negative regulation of protein-containing complex assembly; and protein targeting to vacuole. Located in cytosol and endosome. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MVB12 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (910432..910737)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative ATP-dependent kinase Neighboring gene Cir1p Neighboring gene phosphoserine phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New component of ESCRT-I regulates endosomal sorting complex assembly. Chu T, et al. J Cell Biol, 2006 Dec 4. PMID 17145965, Free PMC Article
  2. Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12. Curtiss M, et al. Mol Biol Cell, 2007 Feb. PMID 17135292, Free PMC Article
  3. ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting. Shields SB, et al. J Cell Biol, 2009 Apr 20. PMID 19380877, Free PMC Article
  4. Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Kostelansky MS, et al. Cell, 2007 May 4. PMID 17442384, Free PMC Article
  5. A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination. Stringer DK, et al. J Cell Biol, 2011 Jan 24. PMID 21242292, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mvb12 may function in regulating the interactions of ESCRT-I with cargo and other proteins of the ESCRT machinery to efficiently coordinate cargo sorting and release of ESCRT-I from the multivesicular body vesicles.
    Title: Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12.
  2. These data support a model in which Mvb12 impacts the selection of multivesicular body cargoes by modulating the cargo recognition capabilities of ESCRT-I.
    Title: Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway.
  3. Mvb12 stabilizes ESCRT-I in an oligomeric, inactive state in the cytosol to ensure that the ordered recruitment and assembly of ESCRT-I and -II is spatially and temporally restricted to the surface of the endosome after activation of the MVB reaction.
    Title: New component of ESCRT-I regulates endosomal sorting complex assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP export IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome transport via multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ESCRT I complex IEA
Inferred from Electronic Annotation
more info
  
part_of ESCRT I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome HDA PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-binding ESCRT-I subunit protein MVB12
NP_011722.3
  • ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers; the ESCRT-I core complex (Stp22p, Vps28p, Srn2p) is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    910432..910737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181335.3 → NP_011722.3  TPA: ubiquitin-binding ESCRT-I subunit protein MVB12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011722.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUY9, P42939
    UniProtKB/TrEMBL
    A6ZUL7, B3LI30, C7GRN9, C8Z999, G2WET5, N1P2J3
    Conserved Domains (1) summary
    pfam09452
    Location:9 → 98
    Mvb12; ESCRT-I subunit Mvb12
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42939.1

Gene LinkOut

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