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PHB2 prohibitin subunit PHB2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853146, updated on 9-Jun-2024

Summary

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Gene symbol
PHB2
Gene description
prohibitin subunit PHB2
Primary source
FungiDB:YGR231C
Locus tag
YGR231C
See related
SGD:S000003463; AllianceGenome:SGD:S000003463; VEuPathDB:YGR231C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrion inheritance; negative regulation of proteolysis; and protein folding. Located in mitochondrial inner membrane. Colocalizes with mitochondrial membrane. Orthologous to human PHB2 (prohibitin 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PHB2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (952548..953480, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Smi1p Neighboring gene Bns1p Neighboring gene Nas6p Neighboring gene Pho81p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of mutations synthetic-lethal to prohibitin 2 null mutants of Saccharomyces cerevisiae. Liu F, et al. Antonie Van Leeuwenhoek, 2006 Feb. PMID 16710639
  2. The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Piper PW, et al. Aging Cell, 2002 Dec. PMID 12882345
  3. A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry. Back JW, et al. Protein Sci, 2002 Oct. PMID 12237468, Free PMC Article
  4. Loss of prohibitins, though it shortens the replicative life span of yeast cells undergoing division, does not shorten the chronological life span of G0-arrested cells. Piper PW, et al. Mech Ageing Dev, 2002 Feb. PMID 11744041
  5. Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. Nijtmans LG, et al. EMBO J, 2000 Jun 1. PMID 10835343, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prohibitin subunit PHB2
NP_011747.2
  • Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    952548..953480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181360.1 → NP_011747.2  TPA: prohibitin subunit PHB2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011747.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV11, P50085
    UniProtKB/TrEMBL
    A0A6A5PWA6, A6ZUN9, B3LI09, B5VJG9, C7GNJ8, C8Z9C3, G2WEV7, N1P410
    Conserved Domains (1) summary
    cd03401
    Location:58 → 252
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50085.2

Gene LinkOut

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