SOL4 6-phosphogluconolactonase SOL4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SOL4
Official Full Name: 6-phosphogluconolactonase SOL4
Primary source: SGD:S000003480
Locus tag: YGR248W
See related: AllianceGenome:SGD:S000003480; FungiDB:YGR248W; VEuPathDB:YGR248W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Located in cytosol. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SOL4 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (985972..986739)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 6-phosphogluconolactonase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6-phosphogluconolactonase activity	IEA Inferred from Electronic Annotation more info
enables 6-phosphogluconolactonase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: 6-phosphogluconolactonase SOL4

NP_011764.3

EC 3.1.1.31

6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

985972..986739

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181377.3 → NP_011764.3 TPA: 6-phosphogluconolactonase SOL4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011764.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV28, P53315

UniProtKB/TrEMBL

B3LHZ2, B5VJI9, C7GNI1, G2WEX4, N1P673

Conserved Domains (1) summary

COG0363
Location:2 → 252

NagB; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]