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RIE1 Rie1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853165, updated on 2-Nov-2024

Summary

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Official Symbol
RIE1
Official Full Name
Rie1p
Primary source
SGD:S000003482
Locus tag
YGR250C
See related
AllianceGenome:SGD:S000003482; FungiDB:YGR250C; VEuPathDB:YGR250C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
WHI8
Summary
Enables mRNA binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in cytoplasmic stress granule. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RIE1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (991176..993521, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 6-phosphogluconolactonase SOL4 Neighboring gene Mga1p Neighboring gene Nop19p Neighboring gene histone acetyltransferase GCN5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rie1 and Sgn1 form an RNA-binding complex that enforces the meiotic entry cell fate decision. Gaspary A, et al. J Cell Biol, 2023 Nov 6. PMID 37638885, Free PMC Article
  2. Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction. Matsui T, et al. PLoS Genet, 2016 Jul. PMID 27437938, Free PMC Article
  3. Analysis of a 17.9 kb region from Saccharomyces cerevisiae chromosome VII reveals the presence of eight open reading frames, including BRF1 (TFIIIB70) and GCN5 genes. Feroli F, et al. Yeast, 1997 Mar 30. PMID 9133742
  4. Stress granules display bistable dynamics modulated by Cdk. Yahya G, et al. J Cell Biol, 2021 Mar 1. PMID 33480968, Free PMC Article
  5. Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1. Wout PK, et al. Eukaryot Cell, 2009 Jul. PMID 19448108, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rie1 and Sgn1 form an RNA-binding complex that enforces the meiotic entry cell fate decision.
    Title: Rie1 and Sgn1 form an RNA-binding complex that enforces the meiotic entry cell fate decision.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rie1p
NP_011766.3
  • RNA binding protein and negative regulator of START; binds mRNA of the G1 cyclin CLN3 to stress granules for translational repression under conditions of stress; recruits the cyclin-dependent protein kinase Cdc28p to stress granules when stressful conditions are relieved, resulting in the dissolution of the granules, and resumption of translation; localizes to stress granules induced by glucose deprivation; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    991176..993521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181379.3 → NP_011766.3  TPA: Rie1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011766.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV30, P53316
    UniProtKB/TrEMBL
    B3LHZ0, B5VJJ1, N1P2N3
    Conserved Domains (2) summary
    TIGR01628
    Location:195 → 757
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12362
    Location:542 → 634
    RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53316.1

Gene LinkOut

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