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TNA1 Tna1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853175, updated on 2-Nov-2024

Summary

Official Symbol
TNA1
Official Full Name
Tna1p
Primary source
SGD:S000003492
Locus tag
YGR260W
See related
AllianceGenome:SGD:S000003492; FungiDB:YGR260W; VEuPathDB:YGR260W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables carboxylic acid transmembrane transporter activity. Involved in quinolinic acid transmembrane transport. Located in cell periphery; fungal-type vacuole; and mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25; gout; porokeratosis; and sialuria. Orthologous to several human genes including SLC17A1 (solute carrier family 17 member 1); SLC17A2 (solute carrier family 17 member 2); and SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See TNA1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1012485..1014089)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mtm1p Neighboring gene ssDNA endodeoxyribonuclease RAD2 Neighboring gene Apl6p Neighboring gene serine/threonine protein kinase BUD32

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
Tna1p
NP_011776.1
  • High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1012485..1014089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181389.1NP_011776.1  TPA: Tna1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011776.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV39, P53322
    UniProtKB/TrEMBL
    B3LHY2, B5VJK2, N1P2P5
    Conserved Domains (1) summary
    cd17327
    Location:87490
    MFS_FEN2_like; Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily