U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SAY1 steryl deacetylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853179, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
SAY1
Official Full Name
steryl deacetylase
Primary source
SGD:S000003495
Locus tag
YGR263C
See related
AllianceGenome:SGD:S000003495; FungiDB:YGR263C; VEuPathDB:YGR263C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables steryl deacetylase activity. Involved in response to toxic substance and sterol metabolic process. Located in endoplasmic reticulum lumen; lipid droplet; and membrane. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SAY1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1017967..1019241, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Apl6p Neighboring gene serine/threonine protein kinase BUD32 Neighboring gene methionine--tRNA ligase MES1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes. Clemente ML, et al. Yeast, 1997 Mar 15. PMID 9090059
  2. An acetylation/deacetylation cycle controls the export of sterols and steroids from S. cerevisiae. Tiwari R, et al. EMBO J, 2007 Dec 12. PMID 18034159, Free PMC Article
  3. Prostate secretory protein 94 inhibits sterol binding and export by the mammalian CAP protein CRISP2 in a calcium-sensitive manner. El Atab O, et al. J Biol Chem, 2022 Mar. PMID 35063506, Free PMC Article
  4. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. Currie E, et al. J Lipid Res, 2014 Jul. PMID 24868093, Free PMC Article
  5. Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution. Castro IG, et al. Elife, 2022 Nov 10. PMID 36354737, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables steryl deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables steryl deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
steryl deacetylase
NP_011779.3
  • Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1017967..1019241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181392.3 → NP_011779.3  TPA: steryl deacetylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011779.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV42, P53324
    UniProtKB/TrEMBL
    B3LHX9, B5VJK5, C8Z9F5, N1P690
    Conserved Domains (1) summary
    pfam10340
    Location:50 → 421
    Say1_Mug180; Steryl acetyl hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53324.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools