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FOL2 GTP cyclohydrolase I [ Saccharomyces cerevisiae S288C ]

Gene ID: 853183, updated on 28-Oct-2024

Summary

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Official Symbol
FOL2
Official Full Name
GTP cyclohydrolase I
Primary source
SGD:S000003499
Locus tag
YGR267C
See related
AllianceGenome:SGD:S000003499; FungiDB:YGR267C; VEuPathDB:YGR267C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTP cyclohydrolase I activity. Involved in folic acid-containing compound biosynthetic process. Located in nucleus. Used to study dystonia. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See FOL2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1025004..1025735, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene methionine--tRNA ligase MES1 Neighboring gene uncharacterized protein Neighboring gene Hua1p Neighboring gene Yta7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pterin and folate salvage. Plants and Escherichia coli lack capacity to reduce oxidized pterins. Noiriel A, et al. Plant Physiol, 2007 Mar. PMID 17220358, Free PMC Article
  2. Disruption of the GTP-cyclohydrolase I gene in Saccharomyces cerevisiae. Nardese V, et al. Biochem Biophys Res Commun, 1996 Jan 5. PMID 8573145
  3. Enhancing the natural folate level in wine using bioengineering and stabilization strategies. Liu Y, et al. Food Chem, 2016 Mar 1. PMID 26471523
  4. GTP-cyclohydrolase I gene mutations in patients with autosomal dominant and recessive GTP-CH1 deficiency: identification and functional characterization of four novel mutations. Garavaglia B, et al. J Inherit Metab Dis, 2004. PMID 15303002
  5. Hexavalent chromium stimulation of riboflavin synthesis in flavinogenic yeast. Fedorovych D, et al. Biometals, 2001 Mar. PMID 11368272

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP cyclohydrolase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP cyclohydrolase I activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP cyclohydrolase I activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in folic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid-containing compound biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pteridine-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrobiopterin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GTP cyclohydrolase I
NP_011783.1
  • GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1025004..1025735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181396.1 → NP_011783.1  TPA: GTP cyclohydrolase I [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011783.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV45, P51601
    UniProtKB/TrEMBL
    A6ZUS4, B3LHX6, B5VJK9, C7GNG6, C8Z9F9, G2WEZ1, N1P4H0
    Conserved Domains (1) summary
    TIGR00063
    Location:61 → 240
    folE; GTP cyclohydrolase I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51601.1

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