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PXR1 telomerase inhibitor [ Saccharomyces cerevisiae S288C ]

Gene ID: 853197, updated on 1-Aug-2024

Summary

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Gene symbol
PXR1
Gene description
telomerase inhibitor
Primary source
FungiDB:YGR280C
Locus tag
YGR280C
See related
SGD:S000003512; AllianceGenome:SGD:S000003512; VEuPathDB:YGR280C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GNO1
Summary
Enables enzyme activator activity and telomerase inhibitor activity. Involved in box C/D RNA 3'-end processing and negative regulation of telomere maintenance via telomerase. Located in nucleolus and nucleoplasm. Used to study cancer. Orthologous to human PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PXR1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1050910..1051725, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene U2-type spliceosomal complex subunit CWC22 Neighboring gene putative family 17 glucosidase Neighboring gene ATP-binding cassette transporter YOR1 Neighboring gene glucan 1,3-beta-glucosidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition. Guglielmi B, et al. J Biol Chem, 2002 Sep 20. PMID 12107183
  2. The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase. Mouffok S, et al. RNA Biol, 2021 Apr. PMID 32882145, Free PMC Article
  3. Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Lin J, et al. Genes Dev, 2004 Feb 15. PMID 14977919, Free PMC Article
  4. Limited portability of G-patch domains in regulators of the Prp43 RNA helicase required for pre-mRNA splicing and ribosomal RNA maturation in Saccharomyces cerevisiae. Banerjee D, et al. Genetics, 2015 May. PMID 25808954, Free PMC Article
  5. The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis. Lebaron S, et al. EMBO J, 2009 Dec 16. PMID 19927118, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
    Title: The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables telomerase inhibitor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables telomerase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in box C/D sno(s)RNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of telomere maintenance via telomerase IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of telomere maintenance via telomerase IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
telomerase inhibitor
NP_011796.1
  • Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1050910..1051725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181409.1 → NP_011796.1  TPA: telomerase inhibitor [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011796.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV57, P53335, Q8TG89
    UniProtKB/TrEMBL
    B3LHW5, C7GNF5, C8Z9H3, G2WF03, N1P2R8
    Conserved Domains (1) summary
    pfam01585
    Location:25 → 70
    G-patch; G-patch domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53335.1

Gene LinkOut

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