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MAL12 alpha-glucosidase MAL12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853209, updated on 28-Oct-2024

Summary

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Official Symbol
MAL12
Official Full Name
alpha-glucosidase MAL12
Primary source
SGD:S000003524
Locus tag
YGR292W
See related
AllianceGenome:SGD:S000003524; FungiDB:YGR292W; VEuPathDB:YGR292W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alpha-1,4-glucosidase activity and glucan 1,4-alpha-maltotriohydrolase activity. Involved in maltose catabolic process and sucrose catabolic process. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See MAL12 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1076599..1078353)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription factor MAL13 Neighboring gene alpha-glucoside permease Neighboring gene seripauperin PAU12 Neighboring gene Cos6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene dosage effects on the synthesis of maltase in yeast. Mowshowitz DB. J Bacteriol, 1979 Mar. PMID 374342, Free PMC Article
  2. Alpha-glucosidase folding during urea denaturation: enzyme kinetics and computational prediction. Wu XQ, et al. Appl Biochem Biotechnol, 2010 Mar. PMID 19418260
  3. A novel competitive class of α-glucosidase inhibitors: (E)-1-phenyl-3-(4-styrylphenyl)urea derivatives. Kim JY, et al. Chembiochem, 2010 Oct 18. PMID 20827790
  4. Novel glycoside of vanillyl alcohol, 4-hydroxy-3-methoxybenzyl-α-D-glucopyranoside: study of enzymatic synthesis, in vitro digestion and antioxidant activity. Veličković D, et al. Bioprocess Biosyst Eng, 2012 Sep. PMID 22307809
  5. Comparison of the molecular interactions of 7'-carboxyalkyl apigenin derivatives with S. cerevisiae α-glucosidase. Qi YJ, et al. Comput Biol Chem, 2017 Apr. PMID 28131019

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural changes in alpha-glucosidase during urea denaturation, was investigated.
    Title: Alpha-glucosidase folding during urea denaturation: enzyme kinetics and computational prediction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,4-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,4-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-amylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucan 1,4-alpha-maltotriohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucan 1,4-alpha-maltotriohydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables oligo-1,6-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sucrose alpha-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in disaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in maltose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maltose catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maltose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sucrose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sucrose catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
alpha-glucosidase MAL12
NP_011808.3
  • Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1076599..1078353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181421.3 → NP_011808.3  TPA: alpha-glucosidase MAL12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011808.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV67, P53341
    UniProtKB/TrEMBL
    A6ZUU5, C7GT48, E1AFY8, F8LG06, G2WF18
    Conserved Domains (2) summary
    cd11333
    Location:15 → 501
    AmyAc_SI_OligoGlu_DGase; Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins
    pfam16657
    Location:511 → 583
    Malt_amylase_C; Maltogenic Amylase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53341.1

Gene LinkOut

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