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Y' element ATP-dependent helicase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853231, updated on 2-Nov-2024

Summary

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Official Full Name
Y' element ATP-dependent helicase
Primary source
SGD:S000003760
Locus tag
YJL225C
See related
AllianceGenome:SGD:S000003760; FungiDB:YJL225C; VEuPathDB:YJL225C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable helicase activity. Predicted to be involved in telomere maintenance via recombination. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Orthologous to human DHX58 (DExH-box helicase 58); RIGI (RNA sensor RIG-I); and IFIH1 (interferon induced with helicase C domain 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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Location:
chromosome: X
Exon count:
2
Sequence:
Chromosome: X; NC_001142.9 (466..6130, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene seripauperin PAU1 Neighboring gene signal sequence-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. Yamada M, et al. J Biol Chem, 1998 Dec 11. PMID 9837911
  2. An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain. Ranjitkar P, et al. Mol Cell, 2010 Nov 12. PMID 21070971, Free PMC Article
  3. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, et al. EMBO J, 1996 May 1. PMID 8641269, Free PMC Article
  4. Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Scherrer T, et al. Genome Biol, 2011. PMID 21232131, Free PMC Article
  5. Distinct roles for Khd1p in the localization and expression of bud-localized mRNAs in yeast. Hasegawa Y, et al. RNA, 2008 Nov. PMID 18805955, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in telomere maintenance via recombination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Y' element ATP-dependent helicase
NP_012311.1
  • Putative Y' element ATP-dependent helicase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    466..6130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181657.1 → NP_012311.1  TPA: Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012311.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVX3, P40887, P40889, Q05371, Q9UQW2
    Conserved Domains (3) summary
    COG0513
    Location:607 → 1133
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam11603
    Location:13 → 88
    Sir1; Regulatory protein Sir1
    cl23921
    Location:1556 → 1609
    YccJ; YccJ-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40889.2

Gene LinkOut

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