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RPL39 ribosomal 60S subunit protein L39 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853250, updated on 3-Nov-2024

Summary

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Official Symbol
RPL39
Official Full Name
ribosomal 60S subunit protein L39
Primary source
SGD:S000003725
Locus tag
YJL189W
See related
AllianceGenome:SGD:S000003725; FungiDB:YJL189W; VEuPathDB:YJL189W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPL46; SPB2
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPL39 (ribosomal protein L39); RPL39L (ribosomal protein L39 like); and RPL39P5 (ribosomal protein L39 pseudogene 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPL39 in Genome Data Viewer
Location:
chromosome: X
Exon count:
2
Sequence:
Chromosome: X; NC_001142.9 (75933..76474)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S14B Neighboring gene ribosomal 40S subunit protein S22A Neighboring gene tyrosine protein kinase SWE1 Neighboring gene alpha-1,2-mannosyltransferase MNN5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation. Micic J, et al. Nucleic Acids Res, 2022 Jun 24. PMID 35639884, Free PMC Article
  2. Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46. Sachs AB, et al. Science, 1990 Mar 2. PMID 2408148
  3. The divergently transcribed genes encoding yeast ribosomal proteins L46 and S24 are activated by shared RPG-boxes. Kraakman LS, et al. Nucleic Acids Res, 1989 Dec 11. PMID 2602141, Free PMC Article
  4. The genes for yeast ribosomal proteins S24 and L46 are adjacent and divergently transcribed. Leer RJ, et al. Nucleic Acids Res, 1985 Feb 11. PMID 4000930, Free PMC Article
  5. Analysis of an essential requirement for the poly(A) binding protein function using cross-species complementation. Chekanova JA, et al. Curr Biol, 2001 Aug 7. PMID 11516954

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation.
    Title: Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation.
  2. Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39
    Title: Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39 of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L39
NP_012346.1
  • Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    75933..76474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181622.1 → NP_012346.1  TPA: ribosomal 60S subunit protein L39 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW02, P04650
    UniProtKB/TrEMBL
    A6ZQE7, B3LPT8, C8ZB30, G2WGI8
    Conserved Domains (1) summary
    COG2167
    Location:1 → 51
    RPL39; Ribosomal protein L39E [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04650.3

Gene LinkOut

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