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CPS1 Gly-Xaa carboxypeptidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853267, updated on 2-Nov-2024

Summary

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Official Symbol
CPS1
Official Full Name
Gly-Xaa carboxypeptidase
Primary source
SGD:S000003708
Locus tag
YJL172W
See related
AllianceGenome:SGD:S000003708; FungiDB:YJL172W; VEuPathDB:YJL172W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables carboxypeptidase activity. Involved in proteolysis involved in protein catabolic process. Located in fungal-type vacuole lumen. Orthologous to human PM20D1 (peptidase M20 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CPS1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (97737..99467)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Kre9p Neighboring gene Rfa3p Neighboring gene Toh1p Neighboring gene Asg7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and sequencing of genomic DNA encoding yeast vacuolar carboxypeptidase yscS. Bordallo J, et al. FEBS Lett, 1991 May 20. PMID 1709881
  2. Carboxypeptidase yscS: gene structure and function of the vacuolar enzyme. Spormann DO, et al. Eur J Biochem, 1991 Apr 23. PMID 2026161
  3. Control of Saccharomyces cerevisiae carboxypeptidase S (CPS1) gene expression under nutrient limitation. Bordallo J, et al. Yeast, 1993 Apr. PMID 8511964
  4. Cis and trans-acting regulatory elements required for regulation of the CPS1 gene in Saccharomyces cerevisiae. Bordallo J, et al. Mol Gen Genet, 1995 Mar 10. PMID 7700231
  5. Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Odorizzi G, et al. Cell, 1998 Dec 11. PMID 9865702

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
is_active_in fungal-type vacuole lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Gly-Xaa carboxypeptidase
NP_012363.1
  • Vacuolar carboxypeptidase S; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3 pathway; expression induced under low-nitrogen conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    97737..99467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181605.1 → NP_012363.1  TPA: Gly-Xaa carboxypeptidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012363.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW16, P27614
    UniProtKB/TrEMBL
    B3LPV2, C8ZB47
    Conserved Domains (1) summary
    cd05674
    Location:91 → 570
    M20_yscS; M20 Peptidase, carboxypeptidase yscS
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27614.2

Gene LinkOut

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