VPS35 retromer subunit VPS35 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: VPS35
Gene description: retromer subunit VPS35
Primary source: FungiDB:YJL154C
Locus tag: YJL154C
See related: SGD:S000003690; AllianceGenome:SGD:S000003690; VEuPathDB:YJL154C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ENV1; GRD9; VPT7
Summary: Contributes to cargo adaptor activity. Involved in protein retention in Golgi apparatus and retrograde transport, endosome to Golgi. Located in endosome and fungal-type vacuole membrane. Part of retromer, cargo-selective complex. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VPS35 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (131101..133935, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results describe a unique allele of VPS35 in S. cerevisiae.
Title: A novel immunodetection screen for vacuolar defects identifies a unique allele of VPS35 in S. cerevisiae.
the R(98) residue, which is part of a conserved PRLYL motif, is critical for Vps35p binding to Vps26p, while both R(98) and residues 733-944 are needed for efficient binding to Vps29p
Title: Structural features of vps35p involved in interaction with other subunits of the retromer complex.
rat Vps35 dominant negative behavior in yeast requires a conserved PRLYL motif involved in retromer assembly
Title: Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to cargo adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to cargo adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein retention in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endosome	IPI Inferred from Physical Interaction more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info
part_of retromer complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of retromer, cargo-selective complex	IEA Inferred from Electronic Annotation more info
part_of retromer, cargo-selective complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: retromer subunit VPS35

NP_012381.1

Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

131101..133935 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181587.1 → NP_012381.1 TPA: retromer subunit VPS35 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012381.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW33, P34110

UniProtKB/TrEMBL

A0A8H4BZG3, A6ZQH8, B3LPW7, C7GPX9, C8ZB66, G2WGL9

Conserved Domains (1) summary

pfam03635
Location:8 → 828

Vps35; Vacuolar protein sorting-associated protein 35