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SFH5 Sfh5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853296, updated on 2-Nov-2024

Summary

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Official Symbol
SFH5
Official Full Name
Sfh5p
Primary source
SGD:S000003681
Locus tag
YJL145W
See related
AllianceGenome:SGD:S000003681; FungiDB:YJL145W; VEuPathDB:YJL145W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables heme binding activity and phosphatidylinositol transfer activity. Involved in several processes, including Golgi to plasma membrane protein transport; phosphatidylinositol metabolic process; and regulation of establishment of cell polarity. Located in cortical endoplasmic reticulum; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SFH5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (145160..146044)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Smt1p Neighboring gene Ids2p Neighboring gene Roq1p Neighboring gene protein transporter TIM17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. Khan D, et al. Elife, 2020 Aug 11. PMID 32780017, Free PMC Article
  2. Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast. Mousley CJ, et al. Biochem Soc Trans, 2006 Jun. PMID 16709158
  3. Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Schnabl M, et al. Eur J Biochem, 2003 Aug. PMID 12869188
  4. Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Li X, et al. Mol Biol Cell, 2000 Jun. PMID 10848624, Free PMC Article
  5. A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis. Ren J, et al. Mol Biol Cell, 2014 Mar. PMID 24403601, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings show that the exocytic signal involves PI delivery Mss4 by Sfh5, generation of PI(4,5)P(2), and PI(4,5)P(2)-dependent regulation of Cdc42 and the actin cytoskeleton.
    Title: A phosphatidylinositol-transfer protein and phosphatidylinositol-4-phosphate 5-kinase control Cdc42 to regulate the actin cytoskeleton and secretory pathway in yeast.
  2. Current view of these reviewers is that Sfh5p (Sec Fourteen Homologue 5) regulates phosphatidylinositol 4,5-diphosphate (PtdIns4,5P2) homoeostasis at the plasma membrane.
    Title: Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol transfer activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane protein transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phospholipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cortical endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sfh5p
NP_012390.1
  • Unusual phosphatidylinositol transfer protein (PITP) that binds heme; similar to Sec14p; founding member of conserved class of fungal hemoproteins; exhibits PI- but not PC-transfer activity; localizes to peripheral endoplasmic reticulum, cytosol, and microsomes; partially relocalizes to plasma membrane upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    145160..146044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181578.1 → NP_012390.1  TPA: Sfh5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012390.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZQI5, D6VW40, P47008, Q6Q535
    UniProtKB/TrEMBL
    B3LPX4, C8ZB74, G2WGM6, N1P3X2
    Conserved Domains (1) summary
    smart00516
    Location:101 → 263
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47008.1

Gene LinkOut

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