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TAX4 Tax4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853362, updated on 18-Sep-2024

Summary

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Official Symbol
TAX4
Official Full Name
Tax4p
Primary source
SGD:S000003619
Locus tag
YJL083W
See related
AllianceGenome:SGD:S000003619; FungiDB:YJL083W; VEuPathDB:YJL083W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in several processes, including cellular response to starvation; fungal-type cell wall organization; and inositol lipid-mediated signaling. Located in phagophore assembly site. Orthologous to several human genes including EHD1 (EH domain containing 1); EHD2 (EH domain containing 2); and EHD3 (EH domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TAX4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (278841..280655)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene GTP-Rho binding exocyst subunit EXO70 Neighboring gene Aly2p Neighboring gene Iml2p Neighboring gene Arp4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recognition specificity of individual EH domains of mammals and yeast. Paoluzi S, et al. EMBO J, 1998 Nov 16. PMID 9822599, Free PMC Article
  2. Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Bugnicourt A, et al. Traffic, 2008 May. PMID 18298591
  3. Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4. Morales-Johansson H, et al. J Biol Chem, 2004 Sep 17. PMID 15265867
  4. A High Copy Suppressor Screen for Autophagy Defects in Saccharomyces arl1Δ and ypt6Δ Strains. Yang S, et al. G3 (Bethesda), 2017 Feb 9. PMID 27974437, Free PMC Article
  5. High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions. Garay E, et al. PLoS Genet, 2014 Feb. PMID 24586198, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Tax4p
NP_012452.1
  • EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    278841..280655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181516.1 → NP_012452.1  TPA: Tax4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWA0, P47030
    UniProtKB/TrEMBL
    B3LQ29, C7GR30, N1NZT8
    Conserved Domains (1) summary
    smart00027
    Location:463 → 557
    EH; Eps15 homology domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47030.1

Gene LinkOut

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