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SCP160 Scp160p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853365, updated on 18-Sep-2024

Summary

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Official Symbol
SCP160
Official Full Name
Scp160p
Primary source
SGD:S000003616
Locus tag
YJL080C
See related
AllianceGenome:SGD:S000003616; FungiDB:YJL080C; VEuPathDB:YJL080C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables G-protein alpha-subunit binding activity and mRNA binding activity. Involved in chemotropism; chromosome organization; and pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in endoplasmic reticulum membrane. Part of polysome. Orthologous to human HDLBP (high density lipoprotein binding protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SCP160 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (285558..289226, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Iml2p Neighboring gene Arp4p Neighboring gene sterol-binding protein Neighboring gene Pry3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of a predicted nuclear localization signal: implications for the intracellular localization and function of the Saccharomyces cerevisiae RNA-binding protein Scp160. Brykailo MA, et al. Nucleic Acids Res, 2007. PMID 17933776, Free PMC Article
  2. Scp160p, a new yeast protein associated with the nuclear membrane and the endoplasmic reticulum, is necessary for maintenance of exact ploidy. Wintersberger U, et al. Yeast, 1995 Aug. PMID 8533468
  3. Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160. Brykailo MA, et al. Nucleic Acids Res, 2007. PMID 17264125, Free PMC Article
  4. Purification and nucleic-acid-binding properties of a Saccharomyces cerevisiae protein involved in the control of ploidy. Weber V, et al. Eur J Biochem, 1997 Oct 1. PMID 9363784
  5. Scp160p, an RNA-binding, polysome-associated protein, localizes to the endoplasmic reticulum of Saccharomyces cerevisiae in a microtubule-dependent manner. Frey S, et al. J Biol Chem, 2001 May 11. PMID 11278502

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Scp160-dependent mRNA trafficking mediates pheromone gradient sensing and chemotropism in yeast.
    Title: Scp160-dependent mRNA trafficking mediates pheromone gradient sensing and chemotropism in yeast.
  2. SESA network comprising Smy2, Eap1, Scp160 and Asc1 , specifically inhibits initiation of translation of POM34 mRNA that encodes an integral membrane protein of the nuclear pore complex
    Title: The SESA network links duplication of the yeast centrosome with the protein translation machinery.
  3. Results indicate that key basic residues within the predicted nuclear localization signal of Scp160 can be altered without severely affecting Scp160 function.
    Title: Analysis of a predicted nuclear localization signal: implications for the intracellular localization and function of the Saccharomyces cerevisiae RNA-binding protein Scp160.
  4. Both conserved and diverged KH domains are essential for Scp160 function.
    Title: Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160.
  5. Scp160p contributes to silencing by helping telomere clustering
    Title: The multi-KH domain protein of Saccharomyces cerevisiae Scp160p contributes to the regulation of telomeric silencing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemotropism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic telomere clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Scp160p
NP_012455.1
  • Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    285558..289226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181513.1 → NP_012455.1  TPA: Scp160p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012455.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWA3, P06105
    UniProtKB/TrEMBL
    C8ZBD2, N1P334
    Conserved Domains (9) summary
    TIGR01612
    Location:170 → 402
    235kDa-fam; reticulocyte binding/rhoptry protein
    cd22446
    Location:172 → 257
    KH-I_ScSCP160_rpt1; first type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
    cd22447
    Location:632 → 707
    KH-I_ScSCP160_rpt2; second type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
    cd22448
    Location:711 → 777
    KH-I_ScSCP160_rpt3; third type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
    cd22449
    Location:780 → 857
    KH-I_ScSCP160_rpt4; fourth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
    cd22450
    Location:859 → 935
    KH-I_ScSCP160_rpt5; fifth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
    cd22451
    Location:940 → 1008
    KH-I_ScSCP160_rpt6; sixth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
    cd22452
    Location:1152 → 1218
    KH-I_ScSCP160_rpt7; seventh type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
    cl11394
    Location:502 → 606
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06105.3

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