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BIT61 Bit61p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853388, updated on 18-Sep-2024

Summary

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Official Symbol
BIT61
Official Full Name
Bit61p
Primary source
SGD:S000003594
Locus tag
YJL058C
See related
AllianceGenome:SGD:S000003594; FungiDB:YJL058C; VEuPathDB:YJL058C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in establishment or maintenance of actin cytoskeleton polarity; fungal-type cell wall organization; and regulation of cell growth. Located in plasma membrane. Part of TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BIT61 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (326242..327873, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene kynurenine--oxoglutarate transaminase Neighboring gene amino acid transporter YHC3 Neighboring gene protein kinase IKS1 Neighboring gene Zap1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Berchtold D, et al. Mol Biol Cell, 2009 Mar. PMID 19144819, Free PMC Article
  2. Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2. Martinez Marshall MN, et al. Mol Biol Cell, 2019 Jun 1. PMID 30969890, Free PMC Article
  3. Methylglyoxal activates the target of rapamycin complex 2-protein kinase C signaling pathway in Saccharomyces cerevisiae. Nomura W, et al. Mol Cell Biol, 2015 Apr. PMID 25624345, Free PMC Article
  4. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Pan Y, et al. Cell Metab, 2011 Jun 8. PMID 21641548, Free PMC Article
  5. Target of rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-rapamycin-2 protein 1 (Avo1) in Saccharomyces cerevisiae. Liao HC, et al. J Biol Chem, 2012 Feb 24. PMID 22207764, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of actin cytoskeleton polarity IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in fungal-type cell wall organization IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of cell growth IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bit61p
NP_012477.1
  • Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p; BIT61 has a paralog, BIT2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    326242..327873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181491.1 → NP_012477.1  TPA: Bit61p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012477.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWC4, P47041
    UniProtKB/TrEMBL
    A6ZPR5, G2WGV8, N1P0V7
    Conserved Domains (1) summary
    pfam08539
    Location:319 → 480
    HbrB; HbrB-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47041.1

Gene LinkOut

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