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LOG1 Log1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853391, updated on 18-Sep-2024

Summary

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Official Symbol
LOG1
Official Full Name
Log1p
Primary source
SGD:S000003591
Locus tag
YJL055W
See related
AllianceGenome:SGD:S000003591; FungiDB:YJL055W; VEuPathDB:YJL055W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable hydrolase activity, hydrolyzing N-glycosyl compounds. Involved in response to purine-containing compound. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LOG1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (333357..334094)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene protein kinase IKS1 Neighboring gene Zap1p Neighboring gene Tim54p Neighboring gene retromer subunit PEP8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of 5-FOA and 5-FU resistance by Saccharomyces cerevisiae YJL055W. Ko N, et al. Yeast, 2008 Feb. PMID 18186026
  2. Gene dosage effects in yeast support broader roles for the LOG1, HAM1 and DUT1 genes in detoxification of nucleotide analogues. Carlsson M, et al. PLoS One, 2018. PMID 29738539, Free PMC Article
  3. A Ham1p-dependent mechanism and modulation of the pyrimidine biosynthetic pathway can both confer resistance to 5-fluorouracil in yeast. Carlsson M, et al. PLoS One, 2013. PMID 24124444, Free PMC Article
  4. Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast. Stepchenkova EI, et al. BMC Genet, 2005 Jun 2. PMID 15932646, Free PMC Article
  5. The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts. Scutenaire J, et al. Nucleic Acids Res, 2023 Jan 25. PMID 35934316, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytokinin riboside 5'-monophosphate phosphoribohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cytokinin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokinin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to purine-containing compound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Log1p
NP_012480.1
  • hypothetical protein; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    333357..334094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181488.1 → NP_012480.1  TPA: Log1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012480.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWC7, P47044
    UniProtKB/TrEMBL
    A6ZPR9, B3LQ55, C7GR57, C8ZBF9, G2WGW1
    Conserved Domains (1) summary
    TIGR00730
    Location:19 → 222
    TIGR00730; TIGR00730 family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47044.1

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