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MHP1 Mhp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853408, updated on 18-Sep-2024

Summary

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Official Symbol
MHP1
Official Full Name
Mhp1p
Primary source
SGD:S000003578
Locus tag
YJL042W
See related
AllianceGenome:SGD:S000003578; FungiDB:YJL042W; VEuPathDB:YJL042W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
A structural constituent of cytoskeleton. Involved in fungal-type cell wall organization and negative regulation of microtubule depolymerization. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MHP1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (361249..365445)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein GYP6 Neighboring gene uncharacterized protein Neighboring gene FG-nucleoporin NSP1 Neighboring gene Nup192p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quality control and substrate-dependent downregulation of the nutrient transporter Fur4. Keener JM, et al. Traffic, 2013 Apr. PMID 23305501, Free PMC Article
  2. Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Lai MH, et al. Yeast, 1997 Mar 15. PMID 9090049
  3. Effect of microtubule-associated protein MHP1 on microtubule assembly and cell cycle progression in Saccharomyces cerevisiae. Irminger-Finger I, et al. Cell Struct Funct, 1998 Aug. PMID 9855114
  4. MHP1, an essential gene in Saccharomyces cerevisiae required for microtubule function. Irminger-Finger I, et al. J Cell Biol, 1996 Dec. PMID 8947554, Free PMC Article
  5. A P4-ATPase protein interaction network reveals a link between aminophospholipid transport and phosphoinositide metabolism. Puts CF, et al. J Proteome Res, 2010 Feb 5. PMID 19968326

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mhp1p
NP_012493.1
  • Microtubule-associated protein involved in microtubule organization; involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    361249..365445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181475.1 → NP_012493.1  TPA: Mhp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012493.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWE2, P43638
    UniProtKB/TrEMBL
    A6ZPT5, N1P8I9
    Conserved Domains (1) summary
    cl39015
    Location:832 → 1015
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43638.1

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