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SYS1 Sys1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853453, updated on 18-Sep-2024

Summary

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Official Symbol
SYS1
Official Full Name
Sys1p
Primary source
SGD:S000003541
Locus tag
YJL004C
See related
AllianceGenome:SGD:S000003541; FungiDB:YJL004C; VEuPathDB:YJL004C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in Golgi to endosome transport; Golgi to plasma membrane protein transport; and protein localization to Golgi apparatus. Located in trans-Golgi network. Is integral component of Golgi membrane. Orthologous to human SYS1 (SYS1 golgi trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SYS1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (431589..432200, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene adenylate cyclase Neighboring gene Cox16p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An acidic sequence of a putative yeast Golgi membrane protein binds COPII and facilitates ER export. Votsmeier C, et al. EMBO J, 2001 Dec 3. PMID 11726510, Free PMC Article
  2. Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p. Tsukada M, et al. J Cell Sci, 1996 Oct. PMID 8923208
  3. Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Setty SR, et al. Nat Cell Biol, 2004 May. PMID 15077114
  4. Arl1p is involved in transport of the GPI-anchored protein Gas1p from the late Golgi to the plasma membrane. Liu YW, et al. J Cell Sci, 2006 Sep 15. PMID 16926193
  5. Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Miller EA, et al. Cell, 2003 Aug 22. PMID 12941277

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to endosome transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sys1p
NP_012530.1
  • Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    431589..432200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181438.1 → NP_012530.1  TPA: Sys1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012530.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWH1, P41544
    UniProtKB/TrEMBL
    A6ZPW3, B3LQ95, C7GUU3, D3UF65, G2WH06, N1P8L1
    Conserved Domains (1) summary
    pfam09801
    Location:20 → 163
    SYS1; Integral membrane protein S linking to the trans Golgi network
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41544.1

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