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HUL4 putative E3 ubiquitin-protein ligase HUL4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853494, updated on 2-Nov-2024

Summary

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Official Symbol
HUL4
Official Full Name
putative E3 ubiquitin-protein ligase HUL4
Primary source
SGD:S000003797
Locus tag
YJR036C
See related
AllianceGenome:SGD:S000003797; FungiDB:YJR036C; VEuPathDB:YJR036C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Located in prospore membrane. Part of TRAMP complex. Orthologous to human HECTD2 (HECT domain E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HUL4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (500713..503391, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Pet191p Neighboring gene DNA-dependent ATPase RAD26 Neighboring gene Mlo127p Neighboring gene Gef1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional domains of the Rsp5 ubiquitin-protein ligase. Wang G, et al. Mol Cell Biol, 1999 Jan. PMID 9858558, Free PMC Article
  2. Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization. La Ferla M, et al. Mutat Res, 2015 Apr. PMID 25779917
  3. Enhanced membrane fusion in sterol-enriched vacuoles bypasses the Vrp1p requirement. Tedrick K, et al. Mol Biol Cell, 2004 Oct. PMID 15254266, Free PMC Article
  4. Ribosome-associated quality control mediates degradation of the premature translation termination product Orf1p of ODC antizyme mRNA. Pradhan AK, et al. FEBS Lett, 2021 Aug. PMID 34109626
  5. Analysis of nitrated proteins in Saccharomyces cerevisiae involved in mating signal transduction. Kang JW, et al. Proteomics, 2015 Jan. PMID 25204828

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of TRAMP complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
putative E3 ubiquitin-protein ligase HUL4
NP_012570.3
  • Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    500713..503391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181694.3 → NP_012570.3  TPA: putative E3 ubiquitin-protein ligase HUL4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012570.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWK9, P40985
    UniProtKB/TrEMBL
    A6ZPZ7, C7GTB8, G2WH42, N1P122
    Conserved Domains (1) summary
    COG5021
    Location:1 → 892
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40985.2

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