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ANB1 translation elongation factor eIF-5A [ Saccharomyces cerevisiae S288C ]

Gene ID: 853506, updated on 17-May-2024

Summary

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Gene symbol
ANB1
Gene description
translation elongation factor eIF-5A
Primary source
FungiDB:YJR047C
Locus tag
YJR047C
See related
SGD:S000003808; AllianceGenome:SGD:S000003808; VEuPathDB:YJR047C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HYP1; TIF51B
Summary
Predicted to enable ribosome binding activity and translation elongation factor activity. Involved in positive regulation of translational elongation and translational frameshifting. Located in cytosolic ribosome. Orthologous to several human genes including EIF5A (eukaryotic translation initiation factor 5A) and EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ANB1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (524908..525381, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tah11p Neighboring gene tRNA-Ser Neighboring gene cytochrome c isoform 1 Neighboring gene NADH/NAD(+) kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxygen regulation of anaerobic and aerobic genes mediated by a common factor in yeast. Lowry CV, et al. Proc Natl Acad Sci U S A, 1984 Oct. PMID 6385009, Free PMC Article
  2. Identification of an upstream repressor site controlling the expression of an anaerobic gene (ANB1) in Saccharomyces cerevisiae. Mehta KD, et al. J Biol Chem, 1989 May 25. PMID 2656688
  3. The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF-4D. Mehta KD, et al. J Biol Chem, 1990 May 25. PMID 2187871
  4. In vitro yeast reconstituted translation system reveals function of eIF5A for synthesis of long polypeptide. Abe T, et al. J Biochem, 2020 May 1. PMID 32053170
  5. Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome. Melnikov S, et al. J Mol Biol, 2016 Sep 11. PMID 27196944, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vitro yeast reconstituted translation system reveals function of eIF5A for synthesis of long polypeptide.
    Title: In vitro yeast reconstituted translation system reveals function of eIF5A for synthesis of long polypeptide.
  2. results link eIF5A function in translation with a role of signal recognition particle in the cell and may help explain the dual effects of eIF5A in differential and general translation
    Title: eIF5A has a function in the cotranslational translocation of proteins into the ER.
  3. Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae.
    Title: Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translational elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of translational termination IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translational termination ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational frameshifting IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translation elongation factor eIF-5A
NP_012581.3
  • Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    524908..525381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181705.3 → NP_012581.3  TPA: translation elongation factor eIF-5A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012581.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWL8, P19211
    UniProtKB/TrEMBL
    A0A6A5PV65, A6ZQ06, B3LQD6, D3UF95, G2WCJ9, G2WH52, N1P131
    Conserved Domains (1) summary
    cl30809
    Location:1 → 154
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19211.3

Gene LinkOut

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