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ISY1 Isy1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853509, updated on 2-Nov-2024

Summary

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Official Symbol
ISY1
Official Full Name
Isy1p
Primary source
SGD:S000003811
Locus tag
YJR050W
See related
AllianceGenome:SGD:S000003811; FungiDB:YJR050W; VEuPathDB:YJR050W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NTC30; UTR3
Summary
Contributes to first spliceosomal transesterification activity. Involved in generation of catalytic spliceosome for second transesterification step and mRNA 3'-splice site recognition. Part of Prp19 complex and spliceosomal complex. Orthologous to human ISY1 (ISY1 splicing factor homolog) and ISY1-RAB43 (ISY1-RAB43 readthrough). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ISY1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (528697..529404)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene cytochrome c isoform 1 Neighboring gene NADH/NAD(+) kinase Neighboring gene fumarate reductase Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of the COR region: a cluster of six genes in the yeast Saccharomyces cerevisiae. Melnick L, et al. Gene, 1990 Mar 15. PMID 2158927
  2. Revised nucleotide sequence of the COR region of yeast Saccharomyces cerevisiae chromosome X. Huang ME, et al. Yeast, 1994 Jun. PMID 7975898
  3. Prp8 positioning of U5 snRNA is linked to 5' splice site recognition. MacRae AJ, et al. RNA, 2018 Jun. PMID 29487104, Free PMC Article
  4. The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. Villa T, et al. Genes Dev, 2005 Aug 15. PMID 16103217, Free PMC Article
  5. Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. Dahan O, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384582, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of the nonessential ISY1 gene improves growth of prp16-302 strains, alleviates stalling, and restores fidelity of branchpoint usage to wild-type levels.
    Title: The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to first spliceosomal transesterification activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of catalytic spliceosome for second transesterification step IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in generation of catalytic spliceosome for second transesterification step IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of catalytic spliceosome for second transesterification step IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA 3'-splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA 3'-splice site recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type catalytic step 1 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of post-mRNA release spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of post-spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of post-spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Isy1p
NP_012584.3
  • Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    528697..529404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181708.3 → NP_012584.3  TPA: Isy1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012584.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWM1, P21374
    UniProtKB/TrEMBL
    B3LQD9, C7GVF6, D3UF97, N1P3F8
    Conserved Domains (1) summary
    pfam06246
    Location:1 → 232
    Isy1; Isy1-like splicing family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21374.2

Gene LinkOut

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