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APS2 Aps2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853521, updated on 17-May-2024

Summary

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Gene symbol
APS2
Gene description
Aps2p
Primary source
FungiDB:YJR058C
Locus tag
YJR058C
See related
SGD:S000003819; AllianceGenome:SGD:S000003819; VEuPathDB:YJR058C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YAP17
Summary
Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Located in clathrin-coated vesicle. Part of AP-2 adaptor complex. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See APS2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (544732..545175, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr Neighboring gene bifunctional thymidylate/uridylate kinase Neighboring gene protein kinase PTK2 Neighboring gene Cbf1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of the YAP19 gene encoding a putative yeast homolog of AP19, the mammalian small chain of the clathrin-assembly proteins. Nakai M, et al. Biochim Biophys Acta, 1993 Sep 23. PMID 8373805
  2. The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex. Phan HL, et al. EMBO J, 1994 Apr 1. PMID 8157009, Free PMC Article
  3. Yeast endocytic adaptor AP-2 binds the stress sensor Mid2 and functions in polarized cell responses. Chapa-y-Lazo B, et al. Traffic, 2014 May. PMID 24460703, Free PMC Article
  4. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cowles CR, et al. Cell, 1997 Oct 3. PMID 9335339
  5. AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. Kirchhausen T, et al. J Biol Chem, 1991 Jun 15. PMID 2040623

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IC
Inferred by Curator
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of AP-2 adaptor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck HDA PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
Aps2p
NP_012592.1
  • Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    544732..545175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181716.1 → NP_012592.1  TPA: Aps2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012592.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWM9, Q00381
    UniProtKB/TrEMBL
    A0A6A5PXF5, A6ZQ17, B3LQE7, C7GME5, C8ZBK7, G2WH63, N1P8Q4
    Conserved Domains (1) summary
    cl38905
    Location:3 → 146
    longin-like; Longin-like domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00381.1

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