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LIA1 deoxyhypusine monooxygenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853534, updated on 4-Aug-2024

Summary

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Gene symbol
LIA1
Gene description
deoxyhypusine monooxygenase
Primary source
FungiDB:YJR070C
Locus tag
YJR070C
See related
SGD:S000003831; AllianceGenome:SGD:S000003831; VEuPathDB:YJR070C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MMD1
Summary
Enables deoxyhypusine monooxygenase activity. Involved in microtubule cytoskeleton organization and peptidyl-lysine modification to peptidyl-hypusine. Located in cytoplasm and nucleus. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LIA1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (569621..570598, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene replication factor C subunit 2 Neighboring gene nucleoside triphosphate pyrophosphohydrolase HAM1 Neighboring gene GTPase NPA3 Neighboring gene bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site. Cano VS, et al. Amino Acids, 2010 Feb. PMID 19956996, Free PMC Article
  2. Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe. Weir BA, et al. Mol Biol Cell, 2004 Apr. PMID 14767070, Free PMC Article
  3. Mapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination. Thompson GM, et al. FEBS Lett, 2003 Dec 18. PMID 14675757
  4. Mutations in the nucleolar proteins Tma23 and Nop6 suppress the malfunction of the Nep1 protein. Buchhaupt M, et al. FEMS Yeast Res, 2007 Sep. PMID 17425675
  5. Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. Park JH, et al. Proc Natl Acad Sci U S A, 2006 Jan 3. PMID 16371467, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Iron is essential for Lia1 activity since its loss renders the enzyme totally inactive.
    Title: Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables deoxyhypusine monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyhypusine monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deoxyhypusine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyhypusine monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-lysine modification to peptidyl-hypusine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine modification to peptidyl-hypusine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-lysine modification to peptidyl-hypusine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
deoxyhypusine monooxygenase
NP_012604.1
  • Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    569621..570598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181728.1 → NP_012604.1  TPA: deoxyhypusine monooxygenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012604.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWP1, P47120
    UniProtKB/TrEMBL
    A6ZQ29, B3LQF7, C7GMD3, C8ZBL8, G2WH75, N1P049
    Conserved Domains (2) summary
    COG1413
    Location:13 → 322
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:187 → 241
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47120.1

Gene LinkOut

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