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aldo-keto reductase superfamily protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 853559, updated on 28-Oct-2024

Summary

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Official Full Name
aldo-keto reductase superfamily protein
Primary source
SGD:S000003857
Locus tag
YJR096W
See related
AllianceGenome:SGD:S000003857; FungiDB:YJR096W; VEuPathDB:YJR096W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aldose reductase (NADPH) activity. Involved in D-xylose catabolic process; arabinose catabolic process; and cellular response to oxidative stress. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (611195..612043)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L43B Neighboring gene Sfc1p Neighboring gene Jjj3p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biocatalytic production of alpha-hydroxy ketones and vicinal diols by yeast and human aldo-keto reductases. Calam E, et al. Chem Biol Interact, 2013 Feb 25. PMID 23295224
  2. Putative xylose and arabinose reductases in Saccharomyces cerevisiae. Träff KL, et al. Yeast, 2002 Oct. PMID 12271459
  3. Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae. Chang Q, et al. Biochim Biophys Acta, 2008 Feb. PMID 17919749, Free PMC Article
  4. Functional studies of aldo-keto reductases in Saccharomyces cerevisiae. Chang Q, et al. Biochim Biophys Acta, 2007 Mar. PMID 17140678, Free PMC Article
  5. Identification and functional evaluation of the reductases and dehydrogenases from Saccharomyces cerevisiae involved in vanillin resistance. Wang X, et al. BMC Biotechnol, 2016 Apr 1. PMID 27036139, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-xylose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in arabinose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arabinose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
aldo-keto reductase superfamily protein
NP_012630.1
  • Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    611195..612043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181754.1 → NP_012630.1  TPA: aldo-keto reductase superfamily protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012630.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWR5, P47137
    UniProtKB/TrEMBL
    A6ZQ52, B3LQI1, C7GMB1, C8ZBP3, N1P073
    Conserved Domains (1) summary
    cd19071
    Location:14 → 266
    AKR_AKR1-5-like; AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47137.1

Gene LinkOut

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