VPS25 ESCRT-II subunit protein VPS25 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: VPS25
Official Full Name: ESCRT-II subunit protein VPS25
Primary source: SGD:S000003863
Locus tag: YJR102C
See related: AllianceGenome:SGD:S000003863; FungiDB:YJR102C; VEuPathDB:YJR102C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: VPL12; VPT25
Summary: Enables structural molecule activity. Involved in ATP export; carbon catabolite repression of transcription from RNA polymerase II promoter by glucose; and protein targeting to vacuole. Located in cytosol. Part of ESCRT II complex. Orthologous to human VPS25 (vacuolar protein sorting 25 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
Title: ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
Crystal structure of full-length Vps25, composed of two homologous winged-helix domains.
Title: Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural molecule activity	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbon catabolite repression of transcription from RNA polymerase II promoter by glucose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT II complex	IDA Inferred from Direct Assay more info	PubMed
part_of ESCRT II complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info