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CPA2 carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853573, updated on 18-Sep-2024

Summary

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Official Symbol
CPA2
Official Full Name
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
Primary source
SGD:S000003870
Locus tag
YJR109C
See related
AllianceGenome:SGD:S000003870; FungiDB:YJR109C; VEuPathDB:YJR109C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. Involved in arginine biosynthetic process. Part of carbamoyl-phosphate synthase complex. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CPA2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (629585..632941, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Abm1p Neighboring gene phosphatidylinositol-3-phosphatase YMR1 Neighboring gene Pxp2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutational analysis of ATP-grasp residues in the two ATP sites of Saccharomyces cerevisiae carbamoyl phosphate synthetase. Eroglu B, et al. Arch Biochem Biophys, 2002 Nov 1. PMID 12392708
  2. Cloning of a yeast gene coding for arginine-specific carbamoyl-phosphate synthetase. Lusty CJ, et al. Proc Natl Acad Sci U S A, 1982 Apr. PMID 6285375, Free PMC Article
  3. Identification of critical amino acid residues of Saccharomyces cerevisiae carbamoyl-phosphate synthetase: definition of the ATP site involved in carboxy-phosphate formation. Zheng W, et al. Biochim Biophys Acta, 1997 Aug 15. PMID 9300807
  4. Yeast carbamyl phosphate synthetase. Structure of the yeast gene and homology to Escherichia coli carbamyl phosphate synthetase. Lusty CJ, et al. J Biol Chem, 1983 Dec 10. PMID 6358221
  5. Critical roles for arginine 1061/1060 and tyrosine 1057 in Saccharomyces cerevisiae arginine-specific carbamoyl-phosphate synthetase. Lim AL, et al. Arch Biochem Biophys, 1997 Mar 15. PMID 9056267

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables carbamoyl-phosphate synthase (ammonia) activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-arginine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-arginine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of carbamoyl-phosphate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
NP_012643.3
  • Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    629585..632941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181767.3 → NP_012643.3  TPA: carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012643.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWS8, P03965
    UniProtKB/TrEMBL
    A6ZQ65, B3LQJ3, B5VLQ3, C7GMA0, C8ZBQ7, G2WHB2, N1P185
    Conserved Domains (1) summary
    TIGR01369
    Location:23 → 1084
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03965.1

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