YMR1 phosphatidylinositol-3-phosphatase YMR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YMR1
Official Full Name: phosphatidylinositol-3-phosphatase YMR1
Primary source: SGD:S000003871
Locus tag: YJR110W
See related: AllianceGenome:SGD:S000003871; FungiDB:YJR110W; VEuPathDB:YJR110W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables mRNA binding activity and phosphatidylinositol-3-phosphatase activity. Involved in phosphatidylinositol dephosphorylation. Located in cytoplasm. Used to study Charcot-Marie-Tooth disease and centronuclear myopathy X-linked. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B1; centronuclear myopathy X-linked; and congenital structural myopathy. Orthologous to several human genes including MTMR6 (myotubularin related protein 6); MTMR7 (myotubularin related protein 7); and MTMR8 (myotubularin related protein 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YMR1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (633615..635681)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ymr1p, a myotubularin phosphatase family member, functions in the control of phosphatidylinositol 3-phosphate dependent signaling and the maintenance of endosomal system integrity.
Title: Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol-3-phosphatase YMR1

NP_012644.1

EC 3.1.3.64

Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

633615..635681

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181768.1 → NP_012644.1 TPA: phosphatidylinositol-3-phosphatase YMR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012644.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWS9, P47147, Q12388

UniProtKB/TrEMBL

B3LQJ4, B5VLQ4, C8ZBQ8, N1P088

Conserved Domains (2) summary

pfam06602
Location:152 → 570

Myotub-related; Myotubularin-like phosphatase domain

cl17171
Location:1 → 44

PH-like; Pleckstrin homology-like domain