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HIR3 Hir3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853605, updated on 18-Sep-2024

Summary

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Official Symbol
HIR3
Official Full Name
Hir3p
Primary source
SGD:S000003901
Locus tag
YJR140C
See related
AllianceGenome:SGD:S000003901; FungiDB:YJR140C; VEuPathDB:YJR140C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HPC1
Summary
Enables transcription corepressor activity. Contributes to DNA binding activity and nucleosome binding activity. Involved in several processes, including DNA replication-independent chromatin assembly; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; and transcription elongation from RNA polymerase II promoter. Located in nucleus. Part of HIR complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HIR3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (690750..695696, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein IML1 Neighboring gene homoserine dehydrogenase Neighboring gene putative polyadenylation protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modeling the regulatory network of histone acetylation in Saccharomyces cerevisiae. Pham H, et al. Mol Syst Biol, 2007. PMID 18091724, Free PMC Article
  2. Host genes that affect the target-site distribution of the yeast retrotransposon Ty1. Huang H, et al. Genetics, 1999 Apr. PMID 10101165, Free PMC Article
  3. The HIR4-1 mutation defines a new class of histone regulatory genes in Saccharomyces cerevisiae. Spector MS, et al. Genetics, 1993 Sep. PMID 8224824, Free PMC Article
  4. The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Prochasson P, et al. Genes Dev, 2005 Nov 1. PMID 16264190, Free PMC Article
  5. Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins. Qian Z, et al. Mol Cell Biol, 1998 Aug. PMID 9671488, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to nucleosome binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of HIR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HIR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HIR complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Hir3p
NP_012674.1
  • Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    690750..695696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181798.1 → NP_012674.1  TPA: Hir3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012674.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWV9, P47171
    UniProtKB/TrEMBL
    A6ZQ96, N1P3Q9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47171.1

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