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IPA1 putative polyadenylation protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 853606, updated on 2-Nov-2024

Summary

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Official Symbol
IPA1
Official Full Name
putative polyadenylation protein
Primary source
SGD:S000003902
Locus tag
YJR141W
See related
AllianceGenome:SGD:S000003902; FungiDB:YJR141W; VEuPathDB:YJR141W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin conjugating enzyme binding activity. Involved in negative regulation of protein ubiquitination; positive regulation of mRNA 3'-end processing; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleus. Orthologous to human UBE3D (ubiquitin protein ligase E3D). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See IPA1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (695906..696949)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene homoserine dehydrogenase Neighboring gene Hir3p Neighboring gene uncharacterized protein Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ipa1 Is an RNA Polymerase II Elongation Factor that Facilitates Termination by Maintaining Levels of the Poly(A) Site Endonuclease Ysh1. Pearson EL, et al. Cell Rep, 2019 Feb 12. PMID 30759400, Free PMC Article
  2. Proteasome Activity Is Influenced by the HECT_2 Protein Ipa1 in Budding Yeast. Lutz AP, et al. Genetics, 2018 May. PMID 29519818, Free PMC Article
  3. Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex. Hill CH, et al. Mol Cell, 2019 Mar 21. PMID 30737185, Free PMC Article
  4. Regulation of the Ysh1 endonuclease of the mRNA cleavage/polyadenylation complex by ubiquitin-mediated degradation. Lee SD, et al. RNA Biol, 2020 May. PMID 32009536, Free PMC Article
  5. An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast. Hansen KG, et al. Science, 2018 Sep 14. PMID 30213914

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative polyadenylation protein
NP_012675.1
  • Protein implicated in pre-mRNA processing and proteasomal degradation; interacts physically and genetically with mRNA cleavage and polyadenylation factors; mutant is impaired in pre-mRNA cleavage and polyadenylation; associates with several Ub-conjugating enzymes and alters Ub-mediated proteasome activity; localizes to both the nucleus and cytosol; contains a HECT_2 domain; homologous to human ubiquitin-protein ligase, UBE3D, a gene implicated in age-related macular degeneration

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    695906..696949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181799.1 → NP_012675.1  TPA: putative polyadenylation protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012675.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWW0, P47172
    UniProtKB/TrEMBL
    B5VLT0, C7GM72, C8ZBU1, G2WHE4, N1P1B6
    Conserved Domains (1) summary
    COG5629
    Location:4 → 347
    COG5629; Predicted metal-binding protein [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47172.1

Gene LinkOut

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